Joint Health Blend with Clinically Tested Extracts Dietary Supplements Non-GMO Joint stiffness and discomfort is also a consequence of aging. With advancing age, there’s an increase in certain cytokines (immune-modulating agents) that contribute to bone health conditions. Tumor necrosis factor (TNF-alpha) is one such agent. These pro-inflammatory agents have been implicated to affect aging joints. Life Extension's Arthro-Immune Joint Support combines two clinically validated plant extracts into one powerful formula to help ease inflammation. Andrographis paniculata has received acclaim for its beneficial effect on inflammation. A Chilean study involved 60 adults who took either 150 mg andrographis extract daily or a placebo. Those taking the extract showed dramatic improvement of several outcomes, including less joint discomfort. For joints that remained tender, the intensity was lessened. Arthro-Immune Joint Support contains PARACTIN Andrographis extract, which has demonstrated its efficacy in easing inflammation in human clinical, in vivo and in vitro studies. Curcumin is a compound that is universally recognized for its impressive antioxidant and fluid-regulating properties. In an as-yet-unpublished double-blind clinical trial, an enhanced absorbing curcumin was shown to have a beneficial effect on inflammation. Arthro-Immune Joint Support also contains BCM-95 Bio-Curcumin, which is considered the gold standard curcumin, with bioavailability far superior to that of most curcumin extracts. Life Extension’s Arthro-Immune Joint Support provides scientifically validated botanical extracts that have been shown to have significant salutary effects on joint health. Just one capsule a day provides a potent serving of PARACTIN and BCM-95 Bio-Curcumin