SERPINC1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91226-50, BS91226-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P01008(Human) P32261(Mouse) Q5M7T5(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC IHC FC

All Applications: WB:1:500-1;1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Antithrombin III (ATIII), an extracellular plasma protein, is a crucial serine protease inhibitor that regulates the coagulation cascade in blood. The inhibitory activity of ATIII is amplified in the presence of heparin. ATIII inhibits Thrombin and Factors IXa, Xa and XIa. Defects in the gene SERPINC1, which encodes for ATIII, can cause ATIII deficiency, an autosomal dominant disease which is a risk factor for hereditary thrombophilia.

Purification and Purity: Protein affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: SERPINC1 polyclonal antibody detects endogenous levels of SERPINC1 protein.

Bioworld Molecular Weight: 53 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of SERPINC1 on different lysates using anti-SERPINC1 antibody at 1/500 dilution.
Positive control:
Lane 1: HepG2
Lane 2: Mouse smooth muscle
Lane 3: Mouse lung, ICC staining SERPINC1 in H22 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: ATIII, SERPINC1, AT3, ANT3, Antithrombin, Antithrombin III, Antithrombin-III, AntithrombinIII, AT 3, AT III, AT3, AT3D, ATIII, Heparin cofactor I, MGC22579, Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1, Serine cysteine proteinase inhibitor clade C member 1, Serine proteinase inhibitor clade C member 1, Serpin C1, Serpin family C member 1, Serpin peptidase inhibitor clade C (antithrombin) member 1, SERPINC1, THPH7,

Immunogen: Recombinant protein within human SERPINC1 aa 150-400.

Conjugate: Unconjugated

Modification: Unmodified