HRAS Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-40406-60, E-AB-40406-120, E-AB-40406-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: HRAS

Target Synonym: C BAS/HAS; C HA RAS1; CTLO; H Ras 1; H RASIDX; HAMSV; HRAS1; Harvey rat sarcoma viral oncogene homolog; K ras; N ras; p19 H RasIDX protein; p21ras; RASH1; Transforming protein p21; vHa RAS

Research Areas: Cell Biology, Signal Transduction, Cell Biology, Epigenetics and Nuclear Signaling, Cancer

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P01112

Background: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

Concentration: 0.78mg/mL

Immunogen: Recombinant Human GTPase HRas protein

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.

Purification Method: Antigen Affinity Purification

Dilution: IHC 1:100-1:300

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only